The unique and memorable design of man-in-the-moon beads has intrigued researchers over the years. These distinctive beads were identified in the 1960s by George Quimby as being chronologically diagnostic of Middle Historic Period sites (1670-1760) in the western Great Lakes region. The present study more clearly defines both the temporal and geographical instances of man-in-the-moon beads while taking into account possible cultural and historical implications. This project has led to the compilation of information regarding many specimens previously unknown to most researchers.